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458 Inflammatory cytokines and autoantibodies implicated in RA pathogenesis can activate ER stress pathways, which in turn drive inflammatory responses that contribute to disease progression

Long-term storage recommended between 4 and 7C

Cespedes M, Jacobs KR, Maruff P, Rembach A, Fowler CJ, Trounson B, et al

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Under oxidative stress conditions, apoptosis signal-regulating kinase 1 (ASK1) dissociates from its inhibitory protein, thioredoxin (Trx), resulting in its activation and initiating the downstream JNK/p38 MAPK apoptotic pathway (89)

Standard HRT options don't work for everyone