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Particular low-function mutations in the cytochrome P450 2D6 metabolic enzyme (CYP2D6) are thought to limit the metabolic pathway that forms codeines physiologically active metabolite, morphine [65], resulting in lack of analgesic effect

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Compared with persistent hypoxia, intermittent hypoxia may be a more moderate pattern of hypoxia

3 Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, Peoples Republic of China