Gastrointestinal Histology As in previous studies [12,13,14,15,16,20,22,23,24], we used a histologic scoring scale adapted from Chui and coworkers [52] for the intestinal tissue damage, scoring 05 (normal to severe) in three categories (mucosal injury, inflammation, and hyperemia/hemorrhage) for a total score of 0 to 15, as described by Lane and coworkers [53]
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Efficacy : In the Phase 2 trial for Type 2 Diabetes (T2D) participants with overweight or obesity, there was a significant placebo-adjusted decrease in HbA1c of 2.3% at the 26-week mark with 4 mg CT-868, indicating a substantial impact on glycemic control
However, semaglutides like Ozempic and Wegovy as well as tizepatide (Mounjaro) can cause fatigue and somnolence (drowsiness)
An animal study demonstrated the potential causative role of the gut microbiota in the development of NAFLD (Reference Aron-Wisnewsky, Vigliotti and Witjes6)
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