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Phase 1 and phase 2 studies of the clinical trial development program for AMG133 are completed with results from phase 1 publicly available (84), while, at this time, phase 2 data have only been disclosed through a company announcement with headline results (85)

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The digested peptide was eluted, vacuum dried, and fractionated using high pH STAGE (Stop-and-go extraction) method into two pools, then subjected to nano-HPLCMS/MS analysis

135,136,137 The transport of uric acid entails multiple genes and proteins, collectively participating in the complex mechanisms of uric acid reabsorption and secretion

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There is evidence that IGF-I and its receptor are expressed in the myocardium and both aortic smooth muscle and endothelial cells[45, 147149], being all of them more sensitive to IGF-I than to insulin[150, 151]