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Allen JM et al

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For example, a systematic review and meta-analysis demonstrated that melatonin improved the fertilization rate and the number of mature oocytes (MII), although it did not significantly affect the clinical pregnancy rate ( In conclusion, melatonin plays a vital role in modulating reproductive functions in both males and females and is a promising therapeutic agent for improving reproductive outcomes due to its antioxidant properties and effects on gene expression and steroid hormone production

This is probably secondary to its ability to block voltage-sensitive sodium channels