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Markers often correlate with outcomes

In addition, in the HepG2 cell experiment, some extrahepatic factors, such as erythroid-2-related factor 2 (NRF2) pathway [58], intestinal metabolite sodium butyrate (NaB) [59], Src homology region 2 domain-containing phosphatase-1 (SHP1)/AMPK [60], sirtuin 1 (SIRT1)/heat shock factor 1/heat shock protein (HSP) [61], and other signaling pathways have also been found to be involved in the regulation of liver lipid synthesis

Crit Rev Toxicol 33, 655780

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The honest answer is that it depends, and it depends most on whether you are actually deficient

In such cases, taking it as a supplement may be the best way to get it in adequate amounts