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SUMMIT: Tirzepatide Improves Outcomes and Quality of Life For Patients With HFpEF and Obesity In patients with obesity and heart failure with preserved ejection fraction (HFpEF), weekly treatment with tirzepatide over approximately two years reduced the risk of worsening heart failure events, based on findings from the SUMMIT trial presented at AHA 2024 and simultaneously published in NEJM

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At 52 weeks, the study found that up to 73% of patients treated with tirzepatide achieved the absence of MASH without the worsening of fibrosis

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By suppressing gastric acid production, omeprazole creates an environment that may reduce the absorption rate of certain oral medications and fat-soluble vitamins like B12, calcium, and magnesium

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