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In conditions like Long COVID and ME/CFS, the body fails to return to homeostasis after the initial infection clears
This is not a marginal change
Bohn et al., 2004), one explanation for differences between different neuronal preparations could be that morphine has a low, but not zero, ability to induce endocytosis and that morphine-induced receptor endocytosis becomes apparent if the levels of GRK and/or arrestin expression are higher as might occur in a different areas within the CNS or cellular infrastructure
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Moving forward, combining natural product research with computational drug discovery, precision medicine, and innovative drug formulations will enhance therapeutic efficacy and accelerate clinical translation
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