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Metformin use in patients with historical contraindications (editorial)

Large-scale trials for methamphetamine are urgently needed

As such, xCT has emerged as a promising target for anticancer therapies, with inhibitors like imidazole ketone erastin (IKE) showing potency in selectively depleting GSH and inducing apoptosis through ROS accumulation 16,17,18,19

High epidemiological reliability denotes the strongest available evidence with no indication of significant variance or bias (26)

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The high variability in adherence and patient management in real-world scenarios likely dilutes the potential maximum efficacy seen under controlled clinical trial conditions