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More recently, the use of IPI504 (Retaspimycin, a synthetic derivative of Geldanamycin), in an in vitro model of age-related macular degeneration (AMD) on senescent ARPE-19 (human arising retinal pigment epithelial cells), leads to a decrease of SA--Galactosidase positive cells, associated with a downregulation of senescence-associated gene expression as well as SASPs secretion, suggesting that in some cases HSP90 inhibitors could also be used as senomorphics 27

Together, these actions support detoxification, mitochondrial efficiency, and healthy aging.*1-13

(3) AOD 9604 Peptide and Obesity In 2004, clinical trials observed the actions of the peptide in 300 obese subjects who were given the peptide for 12 weeks

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