With respect to glycemic control, GLP-1 RAs activate GLP-1 receptors in the pancreas, leading to glucose-mediated enhancement of insulin release and reduction of glucagon release [7]
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Glucagon-like peptide-1 receptor (GLP-1R) is a G protein-coupled receptor widely expressed on the surface of a wide range of cells in the human body, including pancreatic islet , and cells, as well as multiple tissues such as the intestines, stomach, lungs, heart, kidneys, and central nervous system
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