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Nervous system disorders (mainly headache): 30.1% vs placebo: 25.9%
Therefore, there is still the need for the discovery and/or development of a drug candidate characterized by at least a comparable pain-relieving effect to opioids but with a much better safety profile in terms of expected adverse reactions
2009), they are also implicated in a variety of other physiological processes, including stress response, respiration, food intake, gastrointestinal motility, as well as endocrine and immune responses (Le Merrer et al
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