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Research in this context indicates that DSIP may help improve sleep patterns to more closely resemble those of healthy individuals

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Neuroscience and Behavioral Physiology, 22 (4), 275-279

However, leptin replacement does not completely prevent the neuroendocrine adaptations induced by weight loss 1, 3, 5 , indicating the existence of critical additional, but still unknown, starvation signals

Cao, B., Zhang, Y., Chen, J., Wu, P., Dong, Y., & Wang, Y