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Lilly said retatrutide helped relieve obesity-linked conditions including knee pain, sleep apnea, and type 2 diabetes

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Studies of similar medications show 50-70% of lost weight returns within 12-24 months of discontinuation

Theoharis Theoharides on the podcast

This comes as the American College of Cardiology (ACC) released its five top trends in cardiovascular medicine in 2025, including Anti-Obesity Drugs: Cardiovascular Benefit Beyond Weight Loss. The ACC reports that semaglutide and tirzepatide both demonstrate remarkable cardiovascular benefits that extend beyond weight management. Clinical trials show these medications can reduce the risk of major adverse cardiovascular events by up to 20% in patients with obesity and preexisting cardiovascular conditions

He said some of the links already emerging were surprising, suggesting the medications may influence far more than appetite and weight