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The growth hormone secretagogue receptor seems to play a key role in this process, contributing to the overall dynamics observed in research settings

That second effect is not theoretical in GHRH-knockout mice, once-daily CJC-1295 increased total pituitary RNA and GH mRNA in a pattern the authors interpreted as somatotroph proliferation, confirmed by immunohistochemistry [4]

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Inflammatory cytokine production was increased in response to the TLR2 ligand lipoteichoic acid (LTA) and, to a lesser extent, the TLR4 ligand lipopolysaccharide (LPS)

Those receptors are found on the anterior pituitary gland, and their stimulation leads to an acute secretion of GH [7]

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