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The complementary nature of the desirable attributes in GLP-1, GIP and GCG led to the creation of a unimolecular hybridised triagonist with retained and balanced activity across the GLP-1R, GIP receptor (GIPR) and GCGR [1]
Conversely, IGF-1 receptors are also widely expressed but exhibit higher densities in the cortex, hippocampus, and thalamus, with moderate expression in the olfactory bulb, hypothalamus, and cerebellum [95]
More specifically, we identified MTP, an enzyme involved in fatty acid metabolism, as the main interacting protein of GLP-1(2836) (Supplemental Table 2) and validated this by Western blotting (Figure 5B)