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The Pittsburgh Sleep Quality Index (PSQI) reigns as the most widely used questionnaire, gaging sleep quality over the past month through 19 items divided into seven components, classifying individuals as good sleepers or poor sleepers based on a threshold score of 5

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Patients can experience multiple OFF-episodes per day with cumulative daily OFF-time accounting for up to 50% of a patients waking day [3, 4], with significant impact on quality of life [5, 6]

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However, there has not been a comprehensive study directly showing a quantitative increase in telomere lengths, telomerase activity, hTERT expression, and even ALT (Alternative lengthening of Telomeres) activity post-treatment with different doses of epitalon