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A 2015 review in BioMed Research International, the most-cited summary of GHKs biology, describes the peptide stimulating both the synthesis and the breakdown of collagen and glycosaminoglycans, while nudging the metalloproteinases and their inhibitors in tandem

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[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Nowson C, O'Connell S

Oocytes treated with 0.1 mM Epitalon showed significantly improved MMP compared to untreated aged oocytes, demonstrating that Epitalon preserves mitochondrial function during in vitro aging