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Jastreboff et al., SURMOUNT-1 results, NEJM 2023

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[54] Pharmacotherapy [edit] Dopamine antagonists [edit] D 2 receptor antagonists are used to treat gastroparesis by reversing dopamine's inhibition of acetylcholine (ACh) release

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In diabetes, Lilly is also running trials comparing orforglipron to AstraZeneca's Farxiga (dapagliflozin) (ACHIEVE-2) and oral semaglutide (ACHIEVE-3) with results due later this year as well as a head-to-head assessment against insulin glargine (ACHIEVE-4) in overweight T2D patients, and a combination study with insulin (ACHIEVE-5)

Boden G, Chen X, Desantis RA, Kendrick Z