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Another was the discovery that tight junctional permeability is dynamic, altered by systemic inflammation and other factors such as enterotoxins and the volume of fluid absorption [23, 39], initially reported in the early 1980s in clinical studies of intestinal permeability in arthritis and celiac disease patients [37, 40]

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532 In MS models, rapamycin rescues Treg function at the bloodbrain barrier interface, highlighting its potential relevance for neuroinflammatory disease

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