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When glutathione synthesis or recycling is compromised, hydrogen peroxide and lipid peroxides accumulate, oxidizing endothelial membranes and proteins (6)

Higher mitochondrial metabolism in the neurons result in generation of Complex I dependent hydrogen peroxide and neuronal membranes, rich in polyunsaturated fatty acids, are particularly vulnerable to oxidative stress due to their possession of unsaturated double bonds

AM, MZ, and NG searched for literature, wrote the manuscript, reviewed and edited the manuscript

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