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Another Se-dependent enzyme, thioredoxin reductase (TXNRD), supports antioxidant defense by maintaining the redox balance in thyroid cells [17]

These defense mechanisms protect the RBCs not only from ROS generated as a byproduct of released oxygen from hemoglobin but also from ROS generated by NADPH oxidase and, in reticulocytes, from mitochondria-derived ROS during oxidative phosphorylation

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