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Diabetes Obes Metab (2017) 19(2):21627

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Adverse Reactions in the Cardiovascular Outcomes Trial In a double-blind, randomized, placebo-controlled cardiovascular outcomes trial, 27,525 patients received at least one dose of REPATHA or placebo [see Clinical Studies (14)]

The co-primary endpoints were area under the semaglutide plasma concentrationtime curve during a dosing interval at SS (AUC 024h,SS ) and maximum semaglutide plasma concentration at SS ( C max, 024h,SS )

By increasing insulin production, regulating blood sugar and inducing a sense of fullness, these medications lead to significant weight loss