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Overexpressing adiponectin in leptin-deficient ( ob/ob) mice results in decreased plasma glucose and insulin levels, increased liver and muscle insulin sensitivity (which is thought to be due to decreased fat content), significantly increased mass of adipose tissue (these mice were morbidly obese) and a highly significant lowering of plasma triglycerides and FFAs

Others maintain the dose but reduce frequency

SGLT2 inhibitors may improve metabolic profiles in selected non-pregnant patients, but any such use must remain strictly outside pregnancy, under reliable contraception, and with guideline-consistent discontinuation before conception attempts because of urogenital adverse effects and contraindications during pregnancy (155, 156)

These are summarized in Fig

Over time, reusing a spot may lead to lumps or thickened tissue called lipohypertrophy, tenderness, or unpredictable absorption

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