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In that sense, a die-off reaction is sometimes a good sign

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In another study, oral administration of sertraline was found to cause testicular DNA damage and acute testicular injury in male albino rats, as evidenced by significant degeneration and necrosis of germ cells within the seminiferous tubules, as well as interstitial edema and vascular congestion

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Meng TT, Xiao DF, Muhammed A, Deng JY, Chen L, He JH