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The researchers showed that FOXO4-DRI treatment induced apoptosis specifically in senescent chondrocytes while sparing healthy proliferating cells, confirming the selectivity mechanism described in the original Baar et al

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The researchers indicate that in mouse models of CKD or heart failure, the overactivation of the kidney-brain neural circuit leads to increased sympathetic nerve activity targeting both the kidneys and the heart (Cao et al., 2023)