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For de novo NADPH synthesis pathway, correlation studies have revealed that thionicotinamide adenine dinucleotide (NADS) and thionicotinamide adenine dinucleotide phosphate (NADPS), converted from the pro-drug thionicotinamide (TN), act as inhibitors of NADKs through targeting the NAD-binding site of NADKs and decreasing the levels of NADPH

By restoring volume to the tear trough area, this treatment creates a smoother, more rested, and youthful under-eye appearance

doi: 10.1016/j.xcrm.2024.101396