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70,71 Receptor-interacting protein kinase 3 (RIPK3), which is crucial for necroptosis, is found to be diminished in hepatocellular carcinoma (HCC)-associated macrophages, leading to inhibited caspase1-mediated cleavage of PPAR, a process vital for enhancing fatty acid metabolism, including FAO

(ii) contrasting the exacerbation of the inflammatory response

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While constraining, formulation strategies to enhance solubility, absorption, and systemic exposure have demonstrated rational and increasingly validated means to bridge the gap seen between mechanistic efficacy and clinical translation