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So much so, that it has become the top-selling drug in the United States in 2023, with net sales of $13.8 billion

Heterozygous FH (HeFH) is relatively common

We report a case series and draw on this to propose a stepwise treatment approach consisting of lifestyle modifications, metformin, GLP-1 analogues, and the use of flash glucose monitoring technology

Most importantly, know your personal limit and have the courage to stick to it

Eight weeks of supplementation (2 g/day) combined with aerobic training (3 sessions a week) had no significant effects on body weight, BMI and daily dietary intake in obese women [42]

This multi-receptor activity distinguishes it from existing approved agents such as semaglutide and tirzepatide, and it is this broader pharmacological profile that is thought to contribute to its cardiovascular effects, including an increase in resting heart rate