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Curr Med Chem 27(32):53175339 Mats JM, Campos-Sandoval JA (1870) Mrquez J (2018) Glutaminase isoenzymes in the metabolic therapy of cancer

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The Ominous Octet Over the last 30 years our understanding of the pathophysiology of T2DM has revealed that the disease is more complicated than previously appreciated with at least 8 distinct pathogenic abnormalities which collectively comprise the OMINOUS OCTET (2) (Figure 1)

Mitochondrial integrity regulated by lipid metabolism is a cell-intrinsic checkpoint for treg suppressive function

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