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Unlike vitamin B12 deficiency, which produces well-recognised neurological and haematological manifestations, excess B12 does not typically generate a distinct clinical syndrome

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Multiple high-throughput screening campaigns against class B GPCRs had yielded very few small-molecule hits, and those that did emerge typically showed weak activity or failed to progress beyond early preclinical stages

"(The swelling) would accumulate in those areas where I had loose skin

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