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Of note, in STEP 3 intensive behavioral treatment was also administered in both arms, and in STEP 4 all patients were initially assigned to semaglutide 2.4 mg but were randomized 2:1 to semaglutide 2.4 or placebo after 20 weeks 25

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The dose is dependent on how well you tolerate the medication

The recurring findings were that the substances are not well characterised, that human evidence of effectiveness is thin or absent for the proposed routes of administration, and that immunogenicity risk has not been assessed

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