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Some researchers have conceptually explored combining both strategies for potentially synergistic effects on intracellular NAD+ levels, though no published data exists for this specific combination

Recent pharmacokinetic insights suggest that multi-incretin agonists may cross the blood-brain barrier and directly influence neuronal receptors and pathways, providing neuroprotection independent of peripheral glucose levels [33]

Cham: Springer International Publishing

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However, weight loss itself can impact thyroid hormone absorption and requirements, which is why medical oversight during GLP-1 therapy matters for people with thyroid disease