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[PubMed ID: 18380797]

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However, the nuclear pore would not be expected to impose a physical barrier to NAD diffusion between the two compartments (Knockenhauer and Schwartz 2016), as the selective depletion of NMNAT2 or NMNAT1 limits NAD availability only in the cytosol or only in the nucleus (Ryu et al

Nlrp3 / macrophages also presented higher maximal and reserve oxygen consumption rates when compared to Myd88 / and WT cells, which can be explained by the fact that ROS, chronically, lead to reduction in maximal and reserve capacity 95