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The Lancet Diabetes & Endocrinology , 5(1), 4151

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Primary reference: Jastreboff AM et al., New England Journal of Medicine , 2023 Clinical trial registry: Incremental Dose Ladder (Research Context) These values describe clinical trial designs and are not dosing recommendations

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The end product of this reaction (AGE), in turn, induce oxidative stress and accelerate the Maillard reactions ultimately leading to inflammation and the propagation of tissue damage [30, 31, 32]

VPS13D bridges the ER to mitochondria and peroxisomes via Miro