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Trulicity is clinically similar to Ozempic (both are GLP-1 receptor agonists), though head-to-head trials show semaglutide produces slightly greater A1C reduction and weight loss (Nauck et al., Lancet Diabetes & Endocrinology 2021)

N., Kayanoki Y., Kaneto H., et al

FDA has also warned that poor compounding practices can create contamination or potency problems, although that concern applies to compounded drugs generally rather than proving that every compounded GLP-1 product is contaminated

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BPC 157 Safety and Research Limitations: A Regulatory Perspective