While these are different trials with different designs and not a direct head-to-head comparison, the data suggests retatrutide may deliver greater weight loss
There were some differences in results based on the type of medication people used
3,5 In early T2DM managed with lifestyle alone, orforglipron lowered glycated hemoglobin A1c (HbA1c) by -1.24 to -1.48 percentage points over 40 weeks as compared to -0.41 with placebo, with no severe hypoglycemia reported and weight reduction ranging from 4.5% to 7.6%, 3 which led to mean HbA1c levels of 6.5-6.7%
Healthy weight loss maintenance with exercise, GLP-1 receptor agonist, or both combined followed by one year without treatment: A post-treatment analysis of a randomised placebo-controlled trial
This sustained action leads to a far stronger effect on appetite suppression and blood sugar control than what the body can achieve naturally, which is why these medications are highly effective treatments for type 2 diabetes and obesity
Inform patients about the importance of regular testing of renal function and hematological parameters when receiving treatment with XIGDUO XR [see Contraindications (4) and Warnings and Precautions (5.1)]
