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Its key functions include: Antioxidant Defense: The antioxidant glutathione neutralizes free radicals and reduces oxidative stress, preventing cellular damage

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3.5 Metformin significantly increases total glutathione production in CRC cells in vitro As the majority of DNA damage induced by radiation is via indirect action, in particular oxidative damage, and given the demonstrated metformin-induced ROS production in HCT116 and SW837 cells ( Figure 1D ), the impact of metformin treatment on anti-oxidant capacity was assessed