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Microscopically, differentiated (simplex) PeIN is characterized by a thickened epithelium, usually associated with elongated and anastomosing rete ridges, subtle abnormal maturation (enlarged keratinocytes with abundant eosinophilic cytoplasm), whorling and keratin pearl formation (usually in deep rete ridges), prominent intercellular bridges (spongiosis and sometimes acantholysis), and atypical basal cells with hyperchromatic nuclei (116)

J Exp Med 192:10011014 Kehrer JP (2000) The Haber-Weiss reaction and mechanisms of toxicity

This signaling inhibition dampens T cell effector functions, including cytotoxicity and the production and secretion of IFN-, TNF-, and IL-2

A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk