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The actual injection takes only a few minutes and there should be no significant disruption to your daily activities or routine

Moreover, G289A and T337I mutations are located proximal to the ATP-binding pocket of the C-terminal domain, G289A would cause steric conflict with Ser293, and T337I would cause a hydrophobic patch on the protein surface and reduce protein solubility

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Low stomach acid can lead to an increase in intra-abdominal pressure, which can cause the lower esophageal sphincter to open

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