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139,140 Alkyl-adenine DNA glycosylase (AAG) is a critical enzyme that removes methylated DNA bases in BER
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Strict criteria requires the heart rate to rise over 30 in a 10 minute period of time, and or to go above 120 beats per minute, although there are patients who show trends toward postural orthostatic tachycardia that do not quite meet this criterion but do have all of the features of it, and for most practical purposes are treated similarly
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These included a cluster of phosphosites in which the basal phosphorylation was higher in WT-IR than in L973F-IR (II-B, 141 sites), a cluster in which ligand-dependent reduction of phosphorylation was greater in WT-IR than in L973F-IR (II-C, 41 sites), and a cluster in which phosphorylation of proteins was downregulated more by ligands in WT-IR than in L973F-IR (II-D, 28 sites)
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