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Outcomes in the primary analysis were assessed via the intention to treat with the principle of analysis of covariance

Pigmented lesions of the oral cavity: review, differential diagnosis, and case presentations.Journal (Canadian Dental Association)

Reconstituted vials add another problem: every puncture of the septum creates an opportunity for contamination if technique is sloppy

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[3] The practical result of that research is a molecule that behaves very differently from native IGF-1 in laboratory systems, and that has since become a widely stocked reagent for cell-culture applications