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In ACHIEVE-1 , the first of seven Phase 3 studies in people with type 2 diabetes, orforglipron reduced A1C by an average of 1.3% to 1.6% across doses compared to placebo at 40 weeks, starting from a baseline of 8.0%

Janumet XR is contraindicated in severe renal impairment, including an estimated glomerular filtration rate below 30 mL/min/1.73 m2

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Medication interactions can occur through several mechanisms: pharmacokinetic interactions (affecting how drugs are absorbed, distributed, metabolised, or excreted) and pharmacodynamic interactions (affecting how drugs work in the body)