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Enobosarm is currently the most promising of these drugs but, whilst there are a number of clinical trials ongoing, it has not yet (as of 2020) been licenced as a medicine anywhere globally

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On the other hand, sKlotho is also generated by alternative mRNA splicing and the existing ELISA assays were unable to distinguish whether sKlotho results from shedding of the extracellular domain of mKlotho or alternative splicing of its transcript

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