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Currently, tirzepatide and semaglutide are available through prescription in Canada while Retatrutide remains in clinical trials with FDA approval expected in late 2026 or early 2027

Some patients need closer blood pressure monitoring while taking tirzepatide

The SURMOUNT trials showed tirzepatide at 15 mg achieving 15% to 21% weight loss by week 72, compared to semaglutide at 2.4 mg achieving approximately 15% by week 68

The 20.7% figure comes from the STEP-UP trial of 1,742 adults living with obesity, published in NEJM in 2025

But the evidence shows that a complete stoppage will undo a lot of the benefits you accrued over time. Ali also points out that new medications are coming, too

GLP-1 receptor agonists also slow gastric emptying, which enhances feelings of fullness and reduces subsequent food intake