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"Small-molecule-driven hepatocyte differentiation of human pluripotent stem cells"
Significantly enhanced recovery of acute liver failure by liver targeted delivery of stem cells via heparin functionalization
2012 Feb 16
Adequate and well-controlled studies have not been done in pregnant women
Further increases to 1 mg or 2 mg weekly should only occur if tolerated and if additional glycaemic control is needed, following the UK SmPC recommendations
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In an in vitro study, tirzepatide elicited a cAMP response in a human pancreatic -cell line that was significantly higher than that observed for either GLP-1 or GIP alone, indicating a synergistic or additive activation of signaling in pancreatic -cells by GIP and GLP-1 (63)
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