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The short duration limits effectiveness, but sustained-release formulations or combination with longer-acting peptides could improve outcomes while maintaining natural mechanisms

The SURMOUNT trials with tirzepatide demonstrated weight loss exceeding 20% at the highest doses, substantially more than what orforglipron has achieved in Phase 3

Goncalves-Ribeiro S, Diaz-Maroto NG, Berdiel-Acer M, Soriano A, Guardiola J, Martinez-Villacampa M et al

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These medications require a prescription from a qualified provider with a DEA license

At the same time, how the active protein, or peptide, in GLP-1 drugs such as oral semaglutide are absorbed through the gut can vary among peoplecausing differences in effectiveness and tolerability, McCoy says