Wegovy is given as a once-weekly pen injection that is started at a dose of 0.25mg over four weeks
Shaking creates strong shear forces in the liquid that can physically break the peptide chains apart or cause them to unfold and aggregate (clump together), destroying their biological activity
438,439 GLP-1 can also enhance endothelial function by promoting the production of NO, possibly through activating eNOS, thereby affecting vasodilation, anti-inflammatory actions, and anti-atherosclerosis
Providers Clinicians will need to prepare for increased administrative burden related to navigating prior authorization demands
Clinical trials tested weekly doses up to 12 mg for 48 weeks with manageable side effect profiles
GLP-1s affect metabolism, digestion, and appetite