The results of histological microscopic lesion score are shown in Figure 2B
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TGF- signaling is a key driver of this metabolic shift, upregulating enzymes such as PHGDH, PSAT1, PSPH, and SHMT1/2 that are essential for serineglycine biosynthesis and collagen production [17, 18]
Lip Discoloration from Smoking Smoker's melanosis is a specific, well-documented form of lip hyperpigmentation caused by direct stimulation of melanocytes by nicotine and benzopyrenes
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It is doing a lot more than most people realize
