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J Appl Toxicol JAT 32:505520 Laaksonen R, Katajamaa M, Piv H, Sysi-Aho M, Saarinen L, Junni P, Ltjohann D, Smet J, Van Coster R, Seppnen-Laakso T, Lehtimki T, Soini J, Orei M (2006) A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle

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They are complementary often studied together as the Wolverine Stack and human evidence for both remains preclinical

TNF- activates nicotinamide adenine dinucleotide phosphate oxidase (NOX), producing ROS [2], creating a vicious cycle

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